Quality and service improvement (QSI) research employs a broad range of methods to enhance the efficiency of healthcare delivery. QSI research differs from traditional healthcare research and poses unique ethical questions. Since QSI research aims to generate knowledge to enhance quality improvement efforts, should it be considered research for regulatory purposes? Is review by a research ethics committee required? Should healthcare providers be considered research participants? If participation in QSI research entails no more than minimal risk, is consent required? The (...) lack of consensus on answers to these questions highlights the need for ethical guidance. Three distinct approaches to classifying QSI research in accordance with existing ethical principles and regulations can be found in the literature. In the first approach, QSI research is viewed as distinct from other types of healthcare research and does not require regulation. In the second approach, QSI research falls within regulatory guidelines but is exempt from research ethics committee review. In the third approach, QSI research is deemed to be part of the learning healthcare system and, as such, is subject to a different set of ethical principles entirely. In this paper, we critically assess each of these views. While none of these approaches is entirely satisfactory, we argue that use of the ethical principles governing research provides the best means of addressing the numerous questions posed by QSI research. (shrink)

Pragmatic randomized controlled trials are designed to evaluate the effectiveness of interventions in real-world clinical conditions. However, these studies raise ethical issues for researchers and regulators. Our objective is to identify a list of key ethical issues in pragmatic RCTs and highlight gaps in the ethics literature. We conducted a scoping review of articles addressing ethical aspects of pragmatic RCTs. After applying the search strategy and eligibility criteria, 36 articles were included and reviewed using content analysis. Our review identified four (...) major themes: 1) the research-practice distinction; 2) the need for consent; 3) elements that must be disclosed in the consent process; and 4) appropriate oversight by research ethics committees. 1) Most authors reject the need for a research-practice distinction in pragmatic RCTs. They argue that the distinction rests on the presumptions that research participation offers patients less benefit and greater risk than clinical practice, but neither is true in the case of pragmatic RCTs. 2) Most authors further conclude that pragmatic RCTs may proceed without informed consent or with simplified consent procedures when risks are low and consent is infeasible. 3) Authors who endorse the need for consent assert that information need only be disclosed when research participation poses incremental risks compared to clinical practice. Authors disagree as to whether randomization must be disclosed. 4) Finally, all authors view regulatory oversight as burdensome and a practical impediment to the conduct of pragmatic RCTs, and argue that oversight procedures ought to be streamlined when risks to participants are low. The current ethical discussion is framed by the assumption that the function of research oversight is to protect participants from risk. As pragmatic RCTs commonly involve usual care interventions, the risks may be minimal. This leads many to reject the research-practice distinction and question the need for informed consent. But the function of oversight should be understood broadly as protecting the liberty and welfare interest of participants and promoting public trust in research. This understanding, we suggest, will focus discussion on questions about appropriate ethical review for pragmatic RCTs. (shrink)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early (...) cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150–350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing. (shrink)

Curiosity is widely acknowledged as a crucial aspect of children’s development and as an important part of the learning process, with prior research showing associations between curiosity and achievement. Despite this evidence, there is little research on the development of curiosity or on promoting curiosity in school settings, and measures of curiosity promotion in the classroom are absent from the published literature. This article introduces the Curiosity in Classrooms Framework coding protocol, a tool for observing and coding instructional practices that (...) support the promotion of curiosity. We describe the development of the framework and observation instrument and the results of a feasibility study using the protocol, which gives a descriptive overview of curiosity-promoting instruction in 35 elementary-level math lessons. Our discussion includes lessons learned from this work and suggestions for future research using the developed observation tool. (shrink)

Speech unfolds over time, and the cues for even a single phoneme are rarely available simultaneously. Consequently, to recognize a single phoneme, listeners must integrate material over several hundred milliseconds. Prior work contrasts two accounts: (a) a memory buffer account in which listeners accumulate auditory information in memory and only access higher level representations (i.e., lexical representations) when sufficient information has arrived; and (b) an immediate integration scheme in which lexical representations can be partially activated on the basis of early (...) cues and then updated when more information arises. These studies have uniformly shown evidence for immediate integration for a variety of phonetic distinctions. We attempted to extend this to fricatives, a class of speech sounds which requires not only temporal integration of asynchronous cues (the frication, followed by the formant transitions 150–350 ms later), but also integration across different frequency bands and compensation for contextual factors like coarticulation. Eye movements in the visual world paradigm showed clear evidence for a memory buffer. Results were replicated in five experiments, ruling out methodological factors and tying the release of the buffer to the onset of the vowel. These findings support a general auditory account for speech by suggesting that the acoustic nature of particular speech sounds may have large effects on how they are processed. It also has major implications for theories of auditory and speech perception by raising the possibility of an encapsulated memory buffer in early auditory processing. (shrink)

Plant-based milk alternatives–or mylks–have surged in popularity over the past ten years. We consider the politics and consumer subjectivities fostered by mylks as part of the broader trend towards ‘plant-based’ food. We demonstrate how mylk companies inherit and strategically deploy positive framings of milk as wholesome and convenient, as well as negative framings of dairy as environmentally damaging and cruel, to position plant-based as the ‘better’ alternative. By navigating this affective landscape, brands attempt to make mylk as simultaneously palatable and (...) disruptive to the status quo. We examine the politics of mylks through the concept of palatable disruption, where people are encouraged to care about the environment, health, and animal welfare enough to adopt mylks but to ultimately remain consumers of a commodity food. By encouraging consumers to reach for “plant-based” as a way to cope with environmental catastrophe and a life out of balance, mylks promote a neoliberal ethic: they individualize systemic problems and further entrench market mechanisms as solutions, thereby reinforcing the political economy of industrial agriculture. In conclusion, we reflect on the limits of the current plant-based trend for transitioning to more just and sustainable food production and consumption. (shrink)

Two studies examined the use of think aloud (TA) protocol as a means for collecting data of cognitive processes during performance in golf. In study 1, TA was employed to examine if different verbalisation (Level 2 or Level 3 TA) instructions influence performance of high and low skilled golfers. Participants performed 30 putts using TA at either Level 2, Level 3, or no verbalization condition. Although Level 3 verbalization produced a higher volume of verbal data than Level 2, TA at (...) either level 2 or 3 did not impair putting performance compared to no verbalization. Study 2 examined the congruence between data collected via TA at Level 3 and cued retrospective recall of cognitive processes during golf performance. Experienced golfers performed six holes of golf whilst engaging in Level 3 TA. After performance, three semi-structured retrospective interviews were conducted (ten minutes after performance, 24 hours after performance and 48 hours after performance). A comparison of the themes identified large discrepancies between the information reported during TA and at interview, with only 38-41% similarity in variables reported to influence decision making on each hole. Both studies suggest TA is a valuable method for recording cognitive processes of individuals during task performance. TA provides richer verbal data regarding decisions than cued retrospective recall, and TA does not negatively impact performance. (shrink)

Background Pragmatic randomized controlled trials are designed to evaluate the effectiveness of interventions in real-world clinical conditions. However, these studies raise ethical issues for researchers and regulators. Our objective is to identify a list of key ethical issues in pragmatic RCTs and highlight gaps in the ethics literature. Methods We conducted a scoping review of articles addressing ethical aspects of pragmatic RCTs. After applying the search strategy and eligibility criteria, 36 articles were included and reviewed using content analysis. Results Our (...) review identified four major themes: 1) the research-practice distinction; 2) the need for consent; 3) elements that must be disclosed in the consent process; and 4) appropriate oversight by research ethics committees. 1) Most authors reject the need for a research-practice distinction in pragmatic RCTs. They argue that the distinction rests on the presumptions that research participation offers patients less benefit and greater risk than clinical practice, but neither is true in the case of pragmatic RCTs. 2) Most authors further conclude that pragmatic RCTs may proceed without informed consent or with simplified consent procedures when risks are low and consent is infeasible. 3) Authors who endorse the need for consent assert that information need only be disclosed when research participation poses incremental risks compared to clinical practice. Authors disagree as to whether randomization must be disclosed. 4) Finally, all authors view regulatory oversight as burdensome and a practical impediment to the conduct of pragmatic RCTs, and argue that oversight procedures ought to be streamlined when risks to participants are low. Conclusion The current ethical discussion is framed by the assumption that the function of research oversight is to protect participants from risk. As pragmatic RCTs commonly involve usual care interventions, the risks may be minimal. This leads many to reject the research-practice distinction and question the need for informed consent. But the function of oversight should be understood broadly as protecting the liberty and welfare interest of participants and promoting public trust in research. This understanding, we suggest, will focus discussion on questions about appropriate ethical review for pragmatic RCTs. (shrink)

The present study is based on the relationship between philosophy and literature with Nietzsche and Kafka as the main authors studied. The central question of this study is how to comprehend some of Nietzsche’s philosophy in Kafka’s literary pieces? In this way, the goal is to analyze a potential reading of the concepts will of power and nihilism. The text’s proposal develops in two moments: characterizing Nietzsche’s philosophy with the will of power and nihilism concepts as main points of the (...) books considered as “mature” written by this author and presenting Kafka’s piece Carta ao pai as an alternative to overcome nihilism with the main starting point being the relationship between will of power and art characterized by a determined period in Nietzsche’s philosophy as active nihilism. Thus, the text primes at developing not just a descriptive analysis through bibliographic research focusing on the cited manuscripts, but also searching fundaments to arguments made by some commentators of both authors in specific points. (shrink)

ObjectivesTo describe reporting of informed consent in pragmatic trials, justifications for waivers of consent and reporting of alternative approaches to standard written consent. To identify factors associated with (1) not reporting and (2) not obtaining consent.MethodsSurvey of primary trial reports, published 2014–2019, identified using an electronic search filter for pragmatic trials implemented in MEDLINE, and registered in ClinicalTrials.gov.ResultsAmong 1988 trials, 132 (6.6%) did not include a statement about participant consent, 1691 (85.0%) reported consent had been obtained, 139 (7.0%) reported a (...) waiver and 26 (1.3%) reported consent for one aspect (eg, data collection) but a waiver for another (eg, intervention). Of the 165 trials reporting a waiver, 76 (46.1%) provided a justification. Few (53, 2.9%) explicitly reported use of alternative approaches to consent. In multivariable logistic regression analyses, lower journal impact factor (p=0.001) and cluster randomisation (p<0.0001) were significantly associated with not reporting on consent, while trial recency, cluster randomisation, higher-income country settings, health services research and explicit labelling as pragmatic were significantly associated with not obtaining consent (all p<0.0001).DiscussionNot obtaining consent seems to be increasing and is associated with the use of cluster randomisation and pragmatic aims, but neither cluster randomisation nor pragmatism are currently accepted justifications for waivers of consent. Rather than considering either standard written informed consent or waivers of consent, researchers and research ethics committees could consider alternative consent approaches that may facilitate the conduct of pragmatic trials while preserving patient autonomy and the public’s trust in research. (shrink)

Pragmatic comparative effectiveness randomized controlled trials evaluate the effectiveness of one interventions under real-world clinical conditions. The results of ceRCTs are often directly generalizable to everyday clinical practice, providing information critical to decision-making by patients, clinicians, and healthcare policymakers. The PRECIS-2 framework identifies nine domains that serve to score a trial on a continuum between very explanatory to very pragmatic. According to the framework, pragmatic trials may have one or more of the following features: there are fewer eligibility criteria for (...) participants, in an... (shrink)

The problem of religious disagreement between epistemic peers is a potential threat to the epistemic justification of one’s theistic belief. In this paper, I develop a response to this problem which draws on the central epistemological thesis of skeptical theism concerning our inability to make proper judgements about God’s reasons for permitting evil. I suggest that this thesis may extend over to our judgements about God’s reasons for self-revealing, and that when it does so, it can enable theists to remain (...) steadfast amid disagreement with epistemic peers who hold a contrary theistic belief (i.e., atheistic belief). For if we’re unable to make proper judgements about God’s reasons for self-revealing, then for all we know, God has some reason for not revealing Himself to our apparent epistemic peer. Thus, their epistemic credentials needn’t provide reason to reduce one’s confidence to such a degree as to no longer uphold one’s theistic belief. (shrink)

This book (edited by Jonathan Y. Tsou, Jamie Shaw, and Carla Fehr) offers eighteen original historical and philosophical essays focused on values in science, scientific pluralism, and pragmatism. These themes have been central in the work of Matthew J. Brown, and the book frames these topics through an engagement with Brown’s broadly ranging work on values in science. The themes of this book are integrated and unified in the pragmatic and value-laden ideal of science defended by Professor Brown in (...) his fascinating 2020 book, Science and Moral Imagination. Brown's ideal of moral imagination prescribes that scientists should recognize the contingencies in their work as unforced choices, examine morally salient aspects of these decisions, recognize the various interests of relevant stakeholders, explore and construct alternative options, and exercise fair and warranted value judgments to guide those decisions. The interdisciplinary essays in this volume engage with different aspects of Brown's philosophical research on scientific values as well as his historical research on figures such as John Dewey and Paul K. Feyerabend. The international contributors to this volume include distinguished and familiar voices from the values in science literature (e.g., Kevin Elliott, Janet Kourany, and Don Howard) as well as newer voices. The resulting book showcases some of the latest innovative research being done on values, pluralism, and pragmatism, and it will be an important resource for researchers working on values in science. Specific topics addressed in the book include: moral imagination, inductive risk, epistemic priority, the value free ideal of science, values in the contexts of artificial intelligence and medicine, varieties of pluralism (e.g., epistemic, ethical, and cultural), and the structure of scientific communities. The book also features novel historical research on important figures in the traditions of pragmatism, pluralism, and values in science, such as John Dewey, John Stuart Mill, Paul Feyerabend, W. V. O. Quine, Ludwig Fleck, among others. The contributions to the volume represent a broad range of contemporary history and philosophy of science perspectives, which have guided Brown's own work, including socially relevant philosophy of science (SRPoiSE), history of philosophy of science (HOPOS), feminist philosophy of science, and philosophy of science in practice (SPSP). The book will be of interest to a broad audience of researchers working in philosophy of science, philosophy of medicine, history and philosophy of science, and science and technology studies. (shrink)

The extent to which individuals with a variety of cultural backgrounds differ in empathic responsiveness is unknown. This article describes the differences in trait empathy in one independent and one interdependent society (i.e., the US and Iran, respectively). The analysis of data collected from self-reported questionnaires answered by 326 adults indicated a significant difference in the cognitive component of empathy concerning participants’ affiliation to either egocentric or socio-centric society: Iranian participants with interdependent cultural norms, reported higher cognitive empathy compared to (...) American participants who share independent cultural norms. In line with previous studies, gender differences were observed in all subscales of questionnaires, except the Empathy Quotient (EQ). Female participants demonstrated more empathy than males in both samples. Implications for understanding the cross-cultural differences of various components of empathy are discussed. (shrink)

Although theory refers to organizational culture as an important variable in corrupt organizations, only little empirical research has addressed the characteristics of a corrupt organizational culture. Besides some characteristics that go hand in hand with unethical behavior and other features of corrupt organizations, we are still not able to describe a corrupt organizational culture in terms of its underlying assumptions, values, and norms. With a qualitative approach, we studied similarities of organizational culture across different corrupt organizations. In this study, we (...) performed content analysis on interviews of 14 independent experts about their experience with corrupt organizations. With this approach, we gained insights about different corrupt organizations spanning different branches (e.g., government, foreign trade, pharmacy, sports, building industry). We found that corrupt organizations perceive themselves to fight in a war, which leads to their taken-for-granted assumption that “the end justifies the means”. This assumption inspires many values and norms of the organizational culture. An important value in a corrupt organization is “security”, and an important norm is punishment of deviant (i.e., non-corrupt) behavior. Furthermore, managers and employees differ in their perception of organizational culture. While the management endorses values, such as success, results, and performance, and implements these values in their norms of goal setting, employees make use of rationalization strategies and endorse values of security and team spirit. (shrink)

The ethics of the Flexibility In duty hour Requirements for Surgical Trainees trial have been vehemently debated. Views on the ethics of the FIRST trial range from it being completely unethical to wholly unproblematic. The FIRST trial illustrates the complex ethical challenges posed by cluster randomised trials of policy interventions involving healthcare professionals. In what follows, we have three objectives. First, we critically review the FIRST trial controversy, finding that commentators have failed to sufficiently identify and address many of the (...) relevant ethical issues. The 2012 Ottawa Statement on the Ethical Design and Conduct of Cluster Randomized Trials provides researchers and research ethics committees with specific guidance for the ethical design and conduct of CRTs. Second, we aim to demonstrate how the Ottawa Statement provides much-needed clarity to the ethical issues in the FIRST trial, including: research participant identification; consent requirements; gatekeeper roles; benefit-harm analysis and identification of vulnerable participants. We nonetheless also find that the FIRST trial raises ethical issues not adequately addressed by the Ottawa Statement. Hence, third and finally, we raise important questions requiring further ethical analysis and guidance, including: Does clinical equipoise apply to policy interventions with little or no evidence-base? Do healthcare providers have an obligation to participate in research? Does the power-differential in certain healthcare settings render healthcare providers vulnerable to duress and coercion to participant in research? If so, what safeguards might be implemented to protect providers, while allowing important research to proceed? (shrink)

In this report, the phenomenology of two blind users of a sensory substitution device – “The vOICe” – that converts visual images to auditory signals is described. The users both report detailed visual phenomenology that developed within months of immersive use and has continued to evolve over a period of years. This visual phenomenology, although triggered through use of The vOICe, is likely to depend not only on online visualization of the auditory signal but also on the users’ previous (albeit (...) distant) experience of veridical vision (e.g. knowledge of shapes and visual perspective). Once established, the sensory substitution mapping between the auditory and visual domains is not confined to when the device is worn and, thus, may constitute an example of acquired synaesthesia. (shrink)

The chapter argues that we should draw the line between realist and antirealist metaethics according to whether a theory locates the explanation for the special, puzzling features of moral terms and concepts out in the world, with the content of moral thoughts, or inside the head. This taxonomy places Mackie's error theory in the realist category, contrary to the usual scheme. The paper suggests that in looking for the “queerness” of objective value in the metaphysics of moral properties, Mackie makes (...) a mistake parallel to a fantastic mistake made by some of the characters in E. B. White's Charlotte's Web. (shrink)

Abstract -/- “The Obvious Invisibility of the Relationship Between Technology and Social Values” -/- We all too often assume that technology is the product of objective scientific research. And, we assume that technology’s moral value lies in only the moral character of its user. Yet, in order to objectify technology in a manner that removes it from a moral realm, we rely on the assumption that technology is value neutral, i.e., it is independent of all contexts other than the context (...) in which it is used morally or immorally by someone. However, there is a power to technology. At the very least, technology should be seen as reflecting the values that it rises from: a developmental context. Consequently, we can make the invisible moral realm visible as we investigate the relationship between culture and technology. Pragmatically, we can trace how cultural values inform what counts as a scientific question. When we look at the 1980s epidemiological model for AIDS we see how the presuppositions within a culture frame the type of question asked, i.e. What population do we see AIDS occurring in? This question initially leads scientific research away from actual individual behaviors until a different question is asked that leads the question towards behavioral epidemiological models rather than population models. Secondly, we can make visible the circumstance that depicts that what constitutes a scientific problem has a direct relationship to the types of technologies that are developed. We can more clearly see this circular relationship between culture and technology by looking at clinical research and practice regarding heart disease. Men who were dying of diagnosed heart disease were showing symptoms of problems in large arteries of the heart. Women were also dying of heart disease, but since their large arteries were not overwhelmingly compromised they were not being properly diagnosed until recently. Different technologies and protocol were needed to “see” different symptoms in the smaller vessels of women. Thirdly, I show how the types of technology developed, in turn, can create new values or enhance preexisting values within a culture. DNA research can be used to investigate long, unanswered questions about qualitative dimensions of life in quantitative manners. Yet, long held unanswered questions about a biological basis of race or intelligence are themselves rarely challenged as uninteresting or misguided even when they are tied to prejudicial qualitative assumptions if the chance of a “scientific” answer is possible. When existing technologies or modifications of existing technologies can be used they seem to direct human reactions and behaviors in predictable ways. The technologies themselves may be said to direct culture in ethically valenced manners. (shrink)

How do people come to opposite causal judgments about societal problems, such as whether a public health policy reduced COVID‐19 cases? The current research tests an understudied cognitive mechanism in which people may agree about what actually happened (e.g., that a public health policy was implemented and COVID‐19 cases declined), but can be made to disagree about the counterfactual, or what would have happened otherwise (e.g., whether COVID‐19 cases would have declined naturally without intervention) via comparison cases. Across two preregistered (...) studies (total N = 480), participants reasoned about the implementation of a public policy that was followed by an immediate decline in novel virus cases. Study 1 shows that people's judgments about the causal impact of the policy could be pushed in opposite directions by emphasizing comparison cases that imply different counterfactual outcomes. Study 2 finds that people recognize they can use such information to influence others. Specifically, in service of persuading others to support or reject a public health policy, people systematically showed comparison cases implying the counterfactual outcome that aligned with their position. These findings were robust across samples of U.S. college students and politically and socioeconomically diverse U.S. adults. Together, these studies suggest that implied counterfactuals are a powerful tool that individuals can use to manufacture others’ causal judgments and warrant further investigation as a mechanism contributing to belief polarization. (shrink)

ABSTRACT In this essay I set and explore Buch-Hansen and Nielsen’s Critical Realism: Basics and Beyond. I then move on to discuss arising issues relevant to contemporary critical realism, including time, causation, technology and context dilemmas (e.g. reasons as causes and giving offense and taking offense). I then provide a brief elaboration of recent work on and issues for ‘climate emergency’.

Randomized controlled trial trial designs exist on an explanatory-pragmatic spectrum, depending on the degree to which a study aims to address a question of efficacy or effectiveness. As conceptualized by Schwartz and Lellouch in 1967, an explanatory approach to trial design emphasizes hypothesis testing about the mechanisms of action of treatments under ideal conditions, whereas a pragmatic approach emphasizes testing effectiveness of two or more available treatments in real-world conditions. Interest in, and the number of, pragmatic trials has grown substantially (...) in recent years, with increased recognition by funders and stakeholders worldwide of the need for credible evidence to inform clinical decision-making. This increase has been accompanied by the onset of learning healthcare systems, as well as an increasing focus on patient-oriented research. However, pragmatic trials have ethical challenges that have not yet been identified or adequately characterized. The present study aims to explore the views of key stakeholders with respect to ethical issues raised by the design and conduct of pragmatic trials. It is embedded within a large, four-year project that seeks to develop guidance for the ethical design and conduct of pragmatic trials. As a first step, this study will address important gaps in the current empirical literature with respect to identifying a comprehensive range of ethical issues arising from the design and conduct of pragmatic trials. By opening up a broad range of topics for consideration within our parallel ethical analysis, we will extend the current debate, which has largely emphasized issues of consent, to the range of ethical considerations that may flow from specific design choices. Semi-structured interviews with key stakeholders, across multiple jurisdictions, identified based on their known experience and/or expertise with pragmatic trials. We expect that the study outputs will be of interest to a wide range of knowledge users including trialists, ethicists, research ethics committees, journal editors, regulators, healthcare policymakers, research funders and patient groups. All publications will adhere to the Tri-Agency Open Access Policy on Publications. (shrink)

A process of idea filtration in two distinct streams of physics i.e., 1) The dimensionality perspective of spacetime, and 2) The quantum perspective leads us to an understanding of what might be a true reality of all that we perceive. The conclusions arrived at in this paper are a bit perplexing in the sense that our perceived reality could be a manifestation of a combination of 4D + n (n > 0) flat space-time, universal wave function, and cognizance. The work (...) is based on a review and analysis of the main concepts in quantum theory, relativistic physics, and cosmology. Key ideas and conclusions are filtered and logically connected to arrive at what might be a view of the true reality. A significant part of the paper is dedicated to the concept of the “observer” and the “ability of cognizance” that should accompany the “observer”. Though the “observer” is central to modern physics, it is not known what constitutes observation, and the term observer, often open to interpretations, does not have a standard definition and hence, is lacking in clarity. In our analysis, we have argued that the environment, in which the observer-observed system is embedded, emerges as an all-knowing, cognizant, and ideal observer that has the knowledge of the observer-observed system. At a philosophical level, we link to the fundamentals of physics, “consciousness” or “ability of cognizance” as an unavoidable and key element in not only carrying out the observation but perhaps, as believed by many, having a role in shaping the reality perceived. In the review and analysis of another stream of physics, that of General Theory of Relativity (GTR) and cosmology, we examine the question of reality from a cosmological and dimensionality perspective. Research on the 4D and 5D constructs of the universe indicates that the “reality” perceived in 4D spacetime as matter, distance, time, etc., is a manifestation of a higher dimensional 4D + n (n > 0) reality. Theoretical research on this front points towards a 4D-spacetime embedded in a 5D or higher dimensional flat space with matter and energy being a manifestation of the higher dimensions. The flow of logic in this paper leans towards a view of an ultimate true reality that is flat 4D + n (n > 0) space combined with cognizance, universal wave function, and the environment. (shrink)

Until the end of the early 1970s, from a history of economic thought perspective, the mainstream in economics was pluralist, but once neoclassical economics became totally dominant it claimed the mainstream as its own. Since then, alternative views and schools of economics increasingly became minorities in the discipline and were considered heterodox. This book is in honour of John Edward King who has an impressive publication record in the area of economic theory with specific interest in how economic thought in (...) the past shapes current economic theory and enforces certain paths of economic policy and economic development. This book is divided into five themes based on King s interests. The first theme looks at the challenge in trying to reclaim pluralism in economics. The second faces head-on the direct collision of mainstream economics with history of economic thought and heterodox economics. The third addresses classical economic ideas, their central influence in the past and how they can still primarily guide modern pluralist economics. The fourth examines Post Keynesian and Kaleckian economics with a view to providing a more coherent and extensive branch of heterodox economics. The final theme critiques the policy of neoliberalism that has entrenched itself in capitalist economies which have led to financial, industrial, labour, and behavioural/consumerist crises. This text aims to provide a clear path for pluralism to serve the economics discipline as its standard bearer, and to no longer be merely a heterodox challenge to the mainstream. This book is of interest to those who study history of economic thought, political economy and heterodox economics. ". (shrink)

Epithelia can be defined morphologically as tissues that line surfaces, and ultrastructurally with reference to their cells' apico‐basal polarity and possession of specific cell‐cell junctions. Defining the epithelial phenotype at a molecular level is more problematic ‐ while it is easy to name proteins (e.g. keratins) expressed by a “typical” epithelium, no known molecules are expressed by every epithelium but by no other tissues. Cells can differentiate to and from the epithelial state as part of normal development, as a response (...) to disease or when manipulated in culture. Many factors (matrix components, adhesion molecules, growth factors, transcription factors) have been identified that can trigger these transitions of phenotype in specific cases, but to date no general master regulators of the epithelial state have been found. The epithelial state may therefore be controlled by multiple regulatory genes so that there is no single molecule responsible for all of the diverse types of epithelium that exist in higher animals. (shrink)

Like number representation, basic arithmetic seems to be a natural candidate for abstract instantiation in the brain. To investigate this, researchers have examined effects of numeral format on elementary arithmetic (e.g., 4+5 vs. four+five). Different numeral formats often recruit distinct processes for arithmetic, reinforcing the conclusion that number processing is not necessarily abstracted away from numeral format.

In lieu of an abstract, here is a brief excerpt of the content:Hume's Natural History: Religion and "Explanation" M. JAMIE FERREIRA HUME'S BOLDLYSIMPLESTATEMENTof the genesis of religion--that "the anxious concern for happiness, the dread of future misery, the terror of death, the thirst for revenge, the appetite for food and other necessaries" led humankind to see "the first obscure traces of divinity"--is supported by appeals to what he considers plain common sense.' For example, given that at "the first origin (...) of society" (e4) our ancestors were obviously "ignorant and barbarous" (23), anxiously helpless in the face of threatening natural events--hence, obviously with neither the leisure nor the impulse nor the aptitude for serious reflection--it was obviously passionate fears and hopes, not reason, which motivated their beliefs. Given that the mind obviously "rises from inferior to superior," and that humankind obviouslyhasn't "inhabited palaces before huts and cottages or studied geometry before agriculture" (~4), polytheism obviously antedated monotheism. In the course of detailing his commonsensical account of the origin and development of religion, Hume highlights a wide variety of natural tendencies, principles, and propensities which are operative. Keith Yandell offers a recent reading of one such propensity at work in the origin of religion--namely, what Hume calls the "propensity of human nature, which leads into a system, that gives them some satisfaction" (29)--and Yandell explicitly takes it to be a propensity to an "explanatory" system.2 I want to argue in what follows that any reading of Hume's account of religion which highlights an explanatory motivation can be significantly misleading insofar as it obscures the way in which Hume's account differs markedly from other classical genetic accounts which emphasize explanation. ' The Natural History ofReligion, ed. H. E. Root (Stanford, CA, 1956), 28. Further parenthetical page references in the text will be to this work. His later formulation--"The primary religion of mankind arises chiefly from an anxious fear of future events" (65)--recalls Philo's pithy version, namely, "terror is the primary principle of religion" (Dialoguesconcerning Natural Religion, XII). ~Hume's "Inexplicable Mystery": His Views on Religion (Philadelphia, 199o), 9. Hereafter HIM. [5931 594 JOURNAL OF THE HISTORY OF PHILOSOPHY 33:4 OCTOBER 1995 In his account of the "propensity of human nature, which leads into a system, that gives them some satisfaction," Yandell admits that "no explanation is given of exactly what sort of satisfaction is in question," yet he goes on without a pause to speak of how "people accept different and various explanatory systems"; referring to a natural "propensity to understand," he concludes that "for Hume, we need not accept a religious system of explanation, but most of us in fact do so."s I suggest that Yandell's shift from "system" to "explanatory system," which is unheralded, is of crucial significance because the emphasis on explanation tends to call to a reader's mind just the sort of appeal which Hume decisively rejects. I shall argue that Hume draws our attention to and decisively excludes from his account a concept of explanation which actually does play an important role in other parallel accounts--namely, a concept which focuses on the integrity of a broad picture and an ultimate accounting; Hume points to such a concept in his references to the "frame of the universe," "final causes," and the "first rise of the visible system." Such a role might seem to elaborate Hume's appeal to common sense--after all, isn't the natural response to "unknown causes" to try to understand them, and isn't the attempt to understand them the same as looking for an "ultimate" explanation, however crude it might be at the outset? Although this might seem commonsensical to others (as we shall see), I want to argue that what Hume sees at work in the origin of religion is not a search for such an explanation, even a crude one. Rather, on Hume's view the only curiosity at work is a curiosity about how to cope: the propensity to a system is the propensity to the kind of determinacy which is expedient for control, and the only satisfaction the system provides is one in terms of a coping which is independent of truth-seeking... (shrink)

In this paper, I argue that perdurantism is incompatible with priority monism: the view that the universal mereological fusion, U, is fundamental. For the monist’s fundamental object can neither persist by being a trans-temporal object (i.e., a space-time ‘worm’) nor by being an instantaneous stage. If U persisted via being a worm, it would be grounded in its temporal parts, meaning that it would not be fundamental as it would not be ungrounded. If U were a stage, on the other (...) hand, it would face a problem from the possibility of ‘temporal gunk’. But if U persisted by neither being a worm nor a stage, then U could not persist via having temporal parts, and thus perdurantism would be false. Given that a similar combination of perdurantism and priority pluralism also faces a problem from temporal gunk, I conclude that perdurantism does not sit well with mereological based accounts of fundamentality. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume's Natural History: Religion and "Explanation" M. JAMIE FERREIRA HUME'S BOLDLYSIMPLESTATEMENTof the genesis of religion--that "the anxious concern for happiness, the dread of future misery, the terror of death, the thirst for revenge, the appetite for food and other necessaries" led humankind to see "the first obscure traces of divinity"--is supported by appeals to what he considers plain common sense.' For example, given that at "the first origin (...) of society" (e4) our ancestors were obviously "ignorant and barbarous" (23), anxiously helpless in the face of threatening natural events--hence, obviously with neither the leisure nor the impulse nor the aptitude for serious reflection--it was obviously passionate fears and hopes, not reason, which motivated their beliefs. Given that the mind obviously "rises from inferior to superior," and that humankind obviouslyhasn't "inhabited palaces before huts and cottages or studied geometry before agriculture" (~4), polytheism obviously antedated monotheism. In the course of detailing his commonsensical account of the origin and development of religion, Hume highlights a wide variety of natural tendencies, principles, and propensities which are operative. Keith Yandell offers a recent reading of one such propensity at work in the origin of religion--namely, what Hume calls the "propensity of human nature, which leads into a system, that gives them some satisfaction" (29)--and Yandell explicitly takes it to be a propensity to an "explanatory" system.2 I want to argue in what follows that any reading of Hume's account of religion which highlights an explanatory motivation can be significantly misleading insofar as it obscures the way in which Hume's account differs markedly from other classical genetic accounts which emphasize explanation. ' The Natural History ofReligion, ed. H. E. Root (Stanford, CA, 1956), 28. Further parenthetical page references in the text will be to this work. His later formulation--"The primary religion of mankind arises chiefly from an anxious fear of future events" (65)--recalls Philo's pithy version, namely, "terror is the primary principle of religion" (Dialoguesconcerning Natural Religion, XII). ~Hume's "Inexplicable Mystery": His Views on Religion (Philadelphia, 199o), 9. Hereafter HIM. [5931 594 JOURNAL OF THE HISTORY OF PHILOSOPHY 33:4 OCTOBER 1995 In his account of the "propensity of human nature, which leads into a system, that gives them some satisfaction," Yandell admits that "no explanation is given of exactly what sort of satisfaction is in question," yet he goes on without a pause to speak of how "people accept different and various explanatory systems"; referring to a natural "propensity to understand," he concludes that "for Hume, we need not accept a religious system of explanation, but most of us in fact do so."s I suggest that Yandell's shift from "system" to "explanatory system," which is unheralded, is of crucial significance because the emphasis on explanation tends to call to a reader's mind just the sort of appeal which Hume decisively rejects. I shall argue that Hume draws our attention to and decisively excludes from his account a concept of explanation which actually does play an important role in other parallel accounts--namely, a concept which focuses on the integrity of a broad picture and an ultimate accounting; Hume points to such a concept in his references to the "frame of the universe," "final causes," and the "first rise of the visible system." Such a role might seem to elaborate Hume's appeal to common sense--after all, isn't the natural response to "unknown causes" to try to understand them, and isn't the attempt to understand them the same as looking for an "ultimate" explanation, however crude it might be at the outset? Although this might seem commonsensical to others (as we shall see), I want to argue that what Hume sees at work in the origin of religion is not a search for such an explanation, even a crude one. Rather, on Hume's view the only curiosity at work is a curiosity about how to cope: the propensity to a system is the propensity to the kind of determinacy which is expedient for control, and the only satisfaction the system provides is one in terms of a coping which is independent of truth-seeking... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:IntroductionAnthropocene Feminisms: Rethinking the UnthinkableClaire Colebrook and Jami WeinsteinIn her recent lecture on the Anthropocene (to which she adds the Capitalocene and the Chthulucene), Donna Haraway expresses some alarm that after two major insights into what counts as thinkable, it was “anthropos” that became the term for the post-Holocene (Haraway 2014). Haraway declares, with emphasis, that it is “literally unthinkable” to work with the individual unit of “man” if (...) one is to do good intellectual work. For Haraway, the two knowledge events that ought to have precluded the use of the figure of the “anthropos” are: first, the acceptance that any seeming individual is the outcome of a series of complex relations and must be studied as such (so there would be no epoch with anything, let alone “man,” as its first cause), and, second, intellectual inquiry has acknowledged a general becoming-with, such that in order to be anything at all, “one” must be in a dynamic relation. Haraway’s work is exemplary of post-liberal feminist resistance to the figure of man—as subject, agent, and center of knowing. Terms like “Woman” or “the feminine” do not extend the field occupied by man; they instead create a different intensity. So when Haraway questions the “anthropos” of the Anthropocene she neither asks that women, too, be included in those who have scarred the planet, nor does she claim that “Woman” would occupy some innocent outside. Instead, she proposes that one think of the “anthropos” as untimely, as out of sync with an intellectual milieu that theorizes the death of the subject and the eclipse of the human, and has even begun to renounce the notion of life in itself. It is odd that in the face of this destruction of any possibility of thinking by [End Page 167] way of individualism, the epic gesture of the present deploys the figure of the “anthropos,” as it should be unthinkable today to return to the figure of man.When Haraway invokes what is literally unthinkable, and then gestures to the Anthropocene, she suggests that perhaps the figure of the Anthropocene is a form of unthinking, and that it is precisely when complexities, timescales, predictions, manageability, and any form of sustainability ought to disturb and trouble our logics that we cease to think and ask for a single cause for an entire epoch. If this is so, and the “anthropos” of the Anthropocene is a reaction formation, then we might see the skirmishes and turf wars that surround the golden spike1 as diversions. If we spend our time disputing just when it was that man started to change the planet, then we allow a contested point in time to pass itself off as thinking, all the while allowing the intensive multiplicity of what has come to be known as the Anthropocene to remain unthought. By asking when the Anthropocene began, we revive a modified version of the time of man; once again, man is placed as the agent of history, albeit unwittingly, and he can look back upon and assess the past of his own making. Haraway is not alone in suggesting that such conceptions of a single line of time, and a conception of first cause, are highly gendered and racialized. The figure of “man” who creates his own history and recognizes himself as having come into being through a time that is readable is bound up with hegemonic conceptions of modernity, and has long been the target of feminist, poststructuralist, and postcolonial critique (e.g., Foucault 1970; Amin 1989; Grosz 2004). If it is literally unthinkable to do good work from the premises of a methodological individualism, then asking who or what caused the Anthropocene, or when it began, would amount to a form of un-thinking or not-thinking. At the same time, perhaps the Anthropocene is literally unthinkable in a sense that marks a more positive and profound absurdity. Let us accept, following Haraway, that all “good work” both acknowledges the impossibility of accounting for the complexity of life by way of bounded, individual singularity, and dispenses with the exceptional man of reason as its foundation. If we do, what the Anthropocene... (shrink)

Faces are complex stimuli that can be described via intuitive facial features like the eyes, nose, and mouth, “configural” features like the distances between facial landmarks, and features that correspond to computations performed in the early visual system (e.g. oriented edges). With regard to this latter category of descriptors, adult face recognition relies disproportionately on information in specific spatial frequency and orientation bands: Many recognition tasks are performed more accurately when adults have access to mid-range spatial frequencies (8-16 cycles/face) and (...) horizontal orientations (Dakin & Watt, 2009). In the current study, we examined how this information bias develops in middle childhood. We recruited children between the ages of 5-10 years old to participate in a simple categorization task that required them to label images according to whether they depicted a face or a house. Critically, children were presented with face and house images comprised either of primarily horizontal orientation energy, primarily vertical orientation energy, or both horizontal and vertical orientation energy. We predicted that any bias favoring horizontal information over vertical should be more evident in faces than in houses, and also that older children would be more likely to show such a bias than younger children. We designed our categorization task to be sufficiently easy that children would perform at near-ceiling accuracy levels, but with variation in response times that would reflect how they rely on different orientations as a function of age and object category. We found that horizontal bias for face detection (but not house detection) correlated significantly with age, suggesting an emergent category-specific bias for horizontal orientation energy that develops during middle childhood. These results thus suggest that the tuning of high-level recognition to specific low-level visual features takes take place over several years of visual development. (shrink)

The notion that human activity can be characterised in terms of dynamic systems is a well-established alternative to motor schema approaches. Key to a dynamic systems approach is the idea that a system seeks to achieve stable states in the face of perturbation. While such an approach can apply to physical activity, it can be challenging to accept that dynamic systems also describe cognitive activity. In this paper, we argue that creativity, which could be construed as a ‘cognitive’ activity par (...) excellence, arises from the dynamic systems involved in jewellery making. Knowing whether an action has been completed to a ‘good’ standard is a significant issue in considering acts in creative disciplines. When making a piece of jewellery, there a several criteria which can define ‘good’. These are not only the aesthetics of the finished piece but also the impact of earlier actions on subsequent ones. This suggests that the manner in which an action is coordinated is influenced by the criteria by which the product is judged. We see these criteria as indicating states for the system, e.g. in terms of a space of ‘good’ outcomes and a complementary space of ‘bad’ outcomes. The skill of the craftworker is to navigate this space of available states in such a way as to minimise risk, effort and other costs and maximise benefit and quality of the outcome. In terms of postphenomonology, this paper explores Ihde’s human-technology relations and relates these to the concepts developed here. (shrink)

Grapheme-colour synaesthesia is a perceptual experience where graphemes, letters or words evoke a specific colour, which are experienced either as spatially coincident with the grapheme inducer (projector sub-type) or elsewhere, perhaps without a definite spatial location (associator sub-type). Here, we address the question of whether synaesthesia can be rapidly produced using a hypnotic colour suggestion to examine the possibility of ‘hypnotic synaesthesia’, i.e. subjectively experienced colour hallucinations similar to those experienced by projector synaesthetes. We assess the efficacy of this intervention (...) using an “embedded figures” test, in which participants are required to detect a shape (e.g., a square) composed of local graphemic elements. For grapheme-colour synaesthetes, better performance on the task has been linked to a higher proportion of graphemes perceived as coloured. We found no performance benefits on this test when using a hypnotic suggestion, as compared to a no-suggestion control condition. The same result was found when participants were separated according to the degree to which they were susceptible to the suggestion (number of coloured trials perceived). However, we found a relationship between accuracy and subjective reports of colour in those participants who reported a large proportion of coloured trials: trials in which the embedded figure was accurately recognised (relative to trials in which it was not) were associated with reports of more intense colours occupying a greater spatial extent. Collectively, this implies that hypnotic colour was only perceived after shape detection rather than aiding in shape detection via colour-based perceptual grouping. The results suggest that hypnotically induced colours are not directly comparable to synaesthetic ones. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:560 BOOK REVIEWS recent discussion of Christian political theology in On War and Morality is correct, 1) Augustine was more Eusebian than we have generally thought, and 2) Luther was possibly his best exegete. Regarding Forrester's remaining political option, his leapfrogging from Tertullian to the Anabaptists misses the political theology of Western monasticism, which produced not only the witnessing cloister but also a brand of church-state theory (e.g. Gregory (...) VII and Leo IX) quite unlike East· ern Eusebianism. In short, Forrester's spectrum obscures more than it clarifies; the range of qualitatively distinct Christian political theologies is simply wider than he suggests. And while one appreciates a clear discussion of liberation theology, new paths to understanding are not opened. Loyola University Chicago, Illinois MICHAEL J. SCHUCK The Grammar of the Heart: New Essays in Moral Philosophy and Theology. Edited by RICHARD H. BELL. San Francisco: Harper and Row, 1988. Pg. 259 +xxviii. $24.95. Grammar tells us what kind of a thing something is, and this set of essays addresses what Paul Holmer calls the " grammar of faith." This grammar has been traditionally seen, however, in two markedly different ways: as one essay puts the contrast, a grammar of ' rational belief ' as opposed to a "grammar appropriate to affairs of the heart" (Hust· wit, 97). It is the second of these, the character of the grammar of the 'heart,' which these essays as a whole explore, and the sub-title of the 1987 symposium in honor of Holmer from which they are drawn- " Thinking with Kierkegaard and Wittgenstein "-indicates the two main avenues of exploration. Through these, we are told in the introduction, the authors intend to shift the concern of philosophy of religion and theology from questions of " epistemic credentials " to a construe· tive re-valuation of our age-an age which, arguably at least, is still as much " an age without culture " as it was when Wittgenstein first made the complaint. The hook consists of two parts, and each part is introduced by an illustrative selection from Holmer's writings on faith and morality, then followed by a corresponding set of six original essays. The first set of essays, the editor tells us, are " more philosophical," analyzing "the grammar of our modern culture and of religious practices in general," BOOK REVIEWS 561 while the second six are devoted to analyses of specifically moral and Christian concepts. Although the separation of the two may initially seem an artificial one, precisely against the " spirit of both Wittgenstein and Kierkegaard" which the essays are said to exemplify, it does in fact often result in the kind of overlap and repetition which are quite fruitful-for example, as in the mutually illuminating correspondence between the constructive philosophical suggestions about metaphor in the first part (Whittaker) and the presentation of the specifically Kierkegaardian understanding of the metaphorical ' language of love ' in the second part (Walsh). The collection as a whole is indeed in the spirit of Wittgenstein and Kierkegaard by virtue of its imaginative diversity of perspective. Although there is the predictable (and admittedly useful) exploration of the ' grammar of the heart ' in terms of the standardly Kierkegaardian categories of " risk, passion, paradox, and duty " (95), there are also proposals which are both unexpected and exciting. A glance at a few of these will reveal something of the particular character and value of this collection. The centerpiece of the first part is the explicit proposal in two of the essays of an understanding of the grammar of the 'heart ' in which the role and relevance of the private (personal, individualistic) is challenged and rethought in light of the public (social interaction and practice ). The ' heart ' at issue is found at the heart of community; the grammar of the ' heart ' is a grammar of the activities of a life in common, rather than of privatized inwardness or interiority. Glehe-Mcf>ller, for example, examines the relation between two views of religion in Wittgenstein's writings-a first-person (Kierkegaardian) type of religion and a sociological view of religion as a shared phenomenon-arguing that, in the end, despite an explicit adherence to the former throughout his writings, Wittgenstein's intellectual commitments... (shrink)

The notion of Socratic Note Taking is introduced to enhance students’ learning from assigned readings. SNT features students asking questions and answering their own questions while doing the readings. To test the effectiveness of SNT, half the students from two sections of a philosophy course were assigned SNT on alternating weeks. Quizzes each week alternated between the two classes as either high or low stakes in a counterbalanced format. The design was a 2 x 2 x 2 within-participants factorial. On (...) ten-point quizzes, SNT made an average difference of 1.22 points. Furthermore, the results indicate that SNT is particularly effective with weaker students, e.g., we found a nearly three-point increase on ten-point quizzes for the weakest students. (shrink)